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Six triple-target molecules synthesised and now in in vitro testing
After encouraging in-silico results, six TTA small chemical molecules have been synthesised, with 15 more pending, and are now in in vitro testing.
Proof of concept for Triple Target Activation was first confirmed in vitro with phytochemicals known to activate all three targets, and in silico with multiple AI/ML models.
On the strength of those results, six TTA small chemical molecules (SCMs) have now been synthesised. They are being tested in vitro using peripheral blood mononuclear cells from patients with spondyloarthritis, and 15 more molecules are pending.
What we are looking for
- Suppression of the pro-inflammatory panel (TNF, IL-6, MIF, MTOR, IL-17) seen with the phytochemical triple combination
- Induction of IL-10
- A clear ranking of the six molecules to carry into lead-candidate selection
Results are expected soon and will be shared here and with interested partners on request.